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Guest column: Sepsis—A dysregulated host response to infection
by Cesar M. Limjoco, MD
Sepsis has been defined as a toxic response to infection. Sepsis-1 and Sepsis-2 defined it as a systemic inflammatory response to infection. Sepsis-3 now defines it as life-threatening organ dysfunction caused by a dysregulated host response to infection. These definitions are consistent with the fundamental pathophysiology of sepsis: the immune system going awry in the face of an infection.
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